To define whether the genetic variants of Wnt/β-catenin signaling pathway correlated with hypertension, we conducted case–control studies and screened a total of 95 potentially functional variants within 12 Wnt/β-catenin signaling genes (WNT3A, WNT3, WNT4, DKK1, DKK2, LRP5, LRP6, CTNNB1, APC, FZD1, FRZB, SFRP1) mentioned above (Supplementary Table 1). Here, LRP5 is linked to hypertensive disorder.