Compared with WNT3A rs752107 CC genotype, the risk of HF in the CT genotype carriers was nearly increased by 60% (OR = 1.58, 95% CI = 1.21–2.06, P = 0.001) and the risk of IS was increased by 35% (OR = 1.35, 95% CI = 1.01–1.79, P = 0.04). Here, WNT3A is linked to hydrops fetalis.