TNFRSF1B and diabetes mellitus: Overall, the risk of renal progression significantly increased in patients in the highest tertile of TNFR2 than in those in lowest two tertiles of TNFR2, after adjustment for age, sex, presence of diabetes, systolic BP, hsCRP, febuxostat treatment, ACR, and eGFR (HR 4.76, 95% CI 1.79–12.64, P = 0.002) (Table 3).