To investigate the biological function of DGCR5 in ccRCC cell lines, we conducted loss-of-function experiments of DCGR5 and found that transfecting si664 and si523 in A704 cells significantly downregulated DCGR5 isoform-1 expression (Figure 2A and Supplementary Figures 2A,B) and remarkably suppressed cell proliferation (Figure 2B). The gene discussed is DGCR5; the disease is nonpapillary renal cell carcinoma.