In this regard, EVs derived from MSC-TRAIL showed cytotoxicity against lung cancer lines (A549, NCI-H460, and NCI-H727), malignant pleural mesothelioma lines (H2795, H2804, H2810, and H2818), renal cancer lines (RCC10 and HA7-RCC), human breast adenocarcinoma line (MDAMB231; M231), and neuroblastoma line (SHEP-TET) without any cytotoxicity against primary human bronchial epithelial cells (Yuan et al., 2017). This evidence concerns the gene TNFSF10 and renal cell carcinoma.