TNFSF10 and cancer: Conversely, another report has signified that MSC-FL-TRAIL could induce more powerful cytotoxicity against cancer cells than MSC-sTRAIL, and also could defeat cancer cell resistance to recombinant TRAIL, thereby suggesting that MSC delivery of FL-TAIL is superior to MSC delivery of sTRAIL for cancer therapy (Yuan et al., 2015).