Besides, co-culture of IFN-γ-overexpressing BM-MSCs with human chronic myelogenous leukemia (CML) K562 cells led to the potent suppression of the leukemic cell proliferation along with their apoptosis in the experimental groups as well as induction of cell cycle arrest at G1 phase (Li et al., 2006). This evidence concerns the gene IFNG and chronic myelogenous leukemia, BCR-ABL1 positive.