Several studies indicate the colocalization of all three transgelin members with F-actin in certain cell types, namely, TAGLN in fibroblasts (Shapland et al., 1993), TAGLN2 in T-cell immunological synapse (Na et al., 2015), and TAGLN3 in neuroblastoma cells (Mori et al., 2004). Here, TAGLN is linked to neuroblastoma.