SOX2 and central nervous system cancer: In-vivo therapeutic applications: Silencing MALAT1 suppressed proliferation and malignant behavior of glioma, leading to decreased tumor volume and increased survival (18) in vivo via regulating several pathways, including miR-199a/ZHX1 (20), miR-129/SOX2 (17), and miR-384/GOLM1 (27).