Direct interaction of GAS5 and EZH2, in addition to the promotion of miR-424 expression, are among other putative mechanisms for the tumor-suppressing effect of GAS5. miR-424 inhibited AKT3 and regulated the expression of cyclin D1, c-Myc, Bax, and Bcl-2 (214). The gene discussed is BCL2; the disease is neoplasm.