HOTAIR and breast cancer: In summary, this study demonstrates, for the first time, that functional HOTAIR SNPs rs920778 and rs4759314 are related to the risk and prognosis of BC in the northeastern Chinese population, suggesting that these two SNP sites may be involved in the occurrence, development, and metastasis of BC by regulating the expression of HOTAIR. This may have certain significance for future diagnosis, drug development, and prognostic judgment of BC.