The rs1899663 SNP (C > A) is located in the intronic region of HOTAIR, and the AA genotype can increase the expression of HOTAIR by altering the binding affinity of various transcription factors, such as paired box 4, spermatogenic leucine zipper 1, and zinc finger protein 281 (ZFP281) (28) to HOTAIR. The results of studies on the relationship between the rs1899663 SNP and BC susceptibility remain controversial. The gene discussed is HOTAIR; the disease is breast cancer.