ATXN3 and neuroblastoma: For Annexin V/PI flow cytometry analysis, under the condition of MK-2206 treatment, the apoptotic rate of NB cells transfected with ATXN3 siRNA was significantly higher than the control siRNA group (In AS cells, ATXN3 siRNA #1 and #2 vs. control siRNA: 37.0% and 31.4% vs. 16.1%, P<0.001 Figure 3E; In BE2 cells, ATXN3 siRNA vs. control siRNA: 23.0% vs. 16.3%, P<0.01, Figure 3F).