As downregulation of ATXN3 decreased the sensitivity to etoposide in AS and BE2 cells (Figure 4), that was different from the promoting effect of ATXN3 downregulation in the cell death induced by AKT inhibitors (Figure 1 for perifosine, Figure 3 for MK-2206), we investigated the role of ATXN3 in another chemotherapeutic drug, cisplatin, which is commonly used for the treatment of NB patients. Here, AKT1 is linked to neuroblastoma.