In conclusion, downregulation of ATXN3 promoted the cell death of NB cells induced by AKT inhibitors (perifosine and MK-2206) via upregulation of BIM, whereas downregulation of ATNX3 did not enhance, but decreased sensitivity of NB cells to chemotherapeutic drugs (etoposide and cisplatin) by upregulating the expression of Bcl-xl in NB cells. Here, AKT1 is linked to neuroblastoma.