In this study, we found that downregulation of ATXN3 could enhance the cell death induced by AKT inhibitors (perifosine or MK-2206) in NB cells, on one hand, ATXN3 could regulate the activation of AKT, on the other hand, both of perifosine and MK-2206 are AKT inhibitors, thus, downregulation of ATXN3 could increase the sensitivity of NB cells to these agents. Here, ATXN3 is linked to neuroblastoma.