ATXN3 and neuroblastoma: As we found that downregulation of ATXN3 increased the expression of Bcl-xl significantly (as shown in Figure 2A), to investigate whether Bcl-xl mediates the process that downregulation of ATXN3 decreased the sensitivity of NB cells to etoposide and cisplatin, three Bcl-xl siRNAs (#1, #2, and #3) were designed and evaluated, and the Bcl-xl siRNA #3 decreased the expression of Bcl-xl significantly (Figure 6A).