ATXN3 and neuroblastoma: To explore whether BIM mediates the cell death induced by a combination of ATXN3 downregulation and perifosine treatment in NB cells, three BIM siRNAs (#1, #2, and #3) were designed, and all of them could down-regulate the expression of BIM (Figure 2C), and BIM siRNA #1 (marked as BIM siRNA) were used for further study.