ATXN3 and neuroblastoma: To explore the role of ATXN3 in perifosine-induced cell death in NB, we designed three ATXN3 siRNAs (#1, #2, #3), which were shown to down-regulate the endogenous ATXN3 expression (Figure 1A, middle) and perifosine-induced ATXN3 expression (Figure 1A, right).