Plenary studies have shown a correlation between DICER1 syndrome and thyroid cancer (32, 33), and studies revealed that the loss expression of DICER1 was correlated with the malignant status of thyroid cancer cells in a miRNA-dependent manner both in vitro and in vivo, and predicted a worse outcome in patients with thyroid cancers (51, 52); however, whether a mere somatic mutation can lead to thyroid cancer is uncertain. This evidence concerns the gene DICER1 and DICER1-related tumor predisposition.