MAP3K5 and neoplasm: In platelet-mediated tumor metastasis, ADP-induced signaling enhanced the platelet AKT kinase pathway, maintained by apoptosis signal-regulating kinase 1-c-jun N-terminal kinase (ASK1-JNK)/p38-mediated phosphorylation of P2Y12 receptor, thereby linking ADP-induced signaling to platelet mitogen-activated protein kinase (MAPK) signaling pathways (259).