Inhibition of platelet CLEC-2 function in a mouse model of lung cancer significantly reduces thrombus formation and metastatic events after injection of B16F10 melanoma cells, suggesting that interaction between platelet CLEC-2 and cancer-resident PDPN may also enhance thromboembolism, TCIPA and platelet-dependent tumor cell spreading in human patients (33). Here, CLEC1B is linked to melanoma.