Accumulating evidence showed that the deformative and/or dysfunctional mitoribosome was responsible for some devastating malignancies, and a panel of mitoribosome components as well as its assembly factors could be regarded as hallmarks to plot the molecular portraits for specific tumors, such as MRPS23 be significantly in the breast cancer, while DDX28 acts as a risk factor for colorectal cancer (29, 30). The gene discussed is DDX28; the disease is breast cancer.