No matter in the TCGA-BRCA dataset or in the METABRIC dataset, a significant negative-relationship always existed between the survival probability and the expression level of MRPL12, MRPL13 or POP1, meaning that patients should undergo high risk in recurrence and deterioration of breast cancer if they were abundant in the expression of MRPL12, MRPL13 and/or POP1. Naturally, these three RBP-coding genes were constructed into the prognostic model for breast cancer, in addition, the risk score of this model was an independent prognostic factor. This evidence concerns the gene MRPL12 and breast cancer.