The expression levels of ERa, ERb, and PGR proteins in ovarian serous cystadenocarcinoma (OV) and uterine endometrioid adenocarcinoma (UTEA) were validated using in-house tissue specimens, and the relationship between protein levels of ERa, ERb, and PGR and clinicopathological characteristics of OV or UTEA patients was explored. The gene discussed is ESR1; the disease is ovarian serous cystadenocarcinoma.