The expression levels of ERa, ERb, and PGR proteins in ovarian serous cystadenocarcinoma (OV) and uterine endometrioid adenocarcinoma (UTEA) were validated using in-house tissue specimens, and the relationship between protein levels of ERa, ERb, and PGR and clinicopathological characteristics of OV or UTEA patients was explored. This evidence concerns the gene ESR2 and ovarian serous cystadenocarcinoma.