Other indicators of a severe infection include high fever (>39 °C), lymphopenia, elevated liver and renal function tests (aspartate aminotransferase, alanine aminotransferase, creatinine, and urea), elevated acute-phase reactants (C-reactive protein (CRP), procalcitonin (PCT), and serum ferritin), and elevated coagulation profile parameters (prothrombin time, fibrinogen, and D-dimer) [11]. This evidence concerns the gene CRP and lymphopenia.