Viruses continually change through mutations and the gene encoding the S protein of SARS-CoV-2, various mutations have been reported and recently, the United Kingdom (UK) (VOC-202012/01 or VUI-202012/01 or B.1.1.7), Indian (B.1.617), and South Africa (501Y.V2 or 20C/501Y.V2B.1.351) has faced a rapid increase in COVID-19 mediated by new variants (Dawood, 2020; Korber et al., 2020). Here, PROS1 is linked to COVID-19.