CYP2B6 and cancer: For example, CYP2B6*9 and CYP2B6*2 variants which are associated with toxicity and worse treatment outcome were not detected among 172 individuals from Papua New Guinea (Mehlotra et al., 2006; Bray et al., 2010), thus, cancer patients in this region are less likely to experience CYP2B6 pharmacogenetic associated-CP toxicity.