plasma cells, T cells CD8, T cells CD4 memory activated, and T cells follicular helper were reported to play important roles in inhibiting tumors (Kim and Cantor, 2014; Wouters and Nelson, 2018; Panneton et al., 2019), while macrophages and mast cells activated have been proved to be associated with tumor metastasis and poor prognosis (Komohara et al., 2016; Zhang et al., 2020). The gene discussed is CD4; the disease is neoplasm.