TP53 and colorectal cancer: The results showed that the metastasis group was mainly enriched in DNA replication, cell cycle, spliceosome, the P53 signaling pathway, and colorectal cancer, while the non-metastasis group was mainly enriched in arachidonic acid metabolism, the PPAR signaling pathway, and epithelial cell signaling in Helicobacter pylori infection (Figure 2A).