In conclusion, we identified 108 DEGs related to HNSCC metastasis, and constructed a biological signature composed of GNG8, MYO1H, TNFRSF13B, METTL7B, SYT14, and FOXA2 for predicting the prognosis of patients with HNSCC. The gene discussed is SYT14; the disease is head and neck squamous cell carcinoma.