Six key genes related to metastasis of HNSCC were screened out, namely, SYT14, METTL7B, FOXA2, GNG8, TNFRSF13B, and MYO1H, and the expression of these six genes was further verified in 36 samples of HNSCC patients. This evidence concerns the gene SYT14 and head and neck squamous cell carcinoma.