Next, we constructed a novel gene-based signature consisting of 13 genes (FXYD3, MIER3, LINC01133, CHGA, TSPAN1, HRCT1, FRMD3, NR3C2, SLC41A2, NAT1, NAT2, ZG16, and PPARGC1A) for predicting the OS of COAD patients. Here, FXYD3 is linked to colon adenocarcinoma.