Interestingly, dysregulation of NF-kB in glandular epithelial cells results in SS-like features (41), as well as expression of NF-κB at both the mRNA and protein level was up-regulated in SS-lymphoma-BAFF-RHis159Tyr-derived B cells, linking the innate to the adaptive immunity upregulation and lymphoma in SS (42). Here, NFKB1 is linked to lymphoma.