RIGI and COVID-19: The expression level of the viral sensors TLR3, TLR7, DDX58 coding for RIG-I and interferon induced with helicase C domain 1 (IFIH1) coding for MDA-5 were highly variable among patients (Supplementary Figure 2D). TLR7 was the sole sensor significantly overexpressed in COVID-19 patients as compared to controls.