Severe dysfunctions in neutrophils and monocyte populations (17–20), lymphopenia and uncoordinated responses of the three arms of SARS-CoV-2 specific adaptive immunity (CD4+, CD8+ T cell responses and B cell antibody production) were reported in patients with acute COVID-19, particularly in patients >65 years old (21, 22). This evidence concerns the gene CD4 and lymphopenia.