IRF7 and COVID-19: Dysfunctional type I IFN immunity have been attributed to either inherited intrinsic genetic defects in double-stranded RNA sensor TLR3 and interferon regulatory factor 7 (IRF7) (15), or to the production of neutralizing auto-Abs against type I IFNs (16) in respectively, 3.5 and 10.2% of life-threatening COVID-19 patients.