However, compared to that of WT mice with/without infection, the translocation of bacteria to other sterile organs was increased in TLR2-deficient mice, indicating that intestinal integrity was friable in TLR2 mice, especially during CDI, suggesting that TLR2 might also be involved in the regulation of intestinal permeability during CDI. This evidence concerns the gene TLR2 and clostridium difficile infection.