Third, although TLR2 polymorphism was associated with CDI in the univariate analysis, it was not statistically significant in the multivariate analysis, which might be due to the relatively small number of CDI patients in our study; further large-scale study is warranted to clarify the role of TLR2 polymorphisms in CDI. The gene discussed is TLR2; the disease is clostridium difficile infection.