Significantly up-regulated genes in VAT from TG pigs included a series of genes that are associated with T2DM and related complications (Supplementary Figure 4A); for instance aquaglyceroporin 3 (AQP3), retinol binding protein 7 (RBP7), angiopoietin-like 4 (ANGPTL4), and metallothionein 2a (MT2A). This evidence concerns the gene ANGPTL4 and type 2 diabetes mellitus.