Typical ones as β-defensin-1 (DEFB1), growth arrest and DNA damage-inducible gamma (GADD45G), HSP70 binding protein 21 (encoded by TTC36) that protect the organism from and down-regulated in HCC or multiple tumor types, were significantly decreased in liver of TG vs. WT pigs. Here, DEFB1 is linked to hepatocellular carcinoma.