TG pigs had highly functional coincidence with a detailed transcriptional network analysis on human NASH, which introduced that firstly, a NASH-linked gene signature was enriched in inflammatory responses, antigen presentation and cytotoxic cells; and secondly, hepatic CD8+ T cells, conventional dendritic cells and cytotoxic cell in the blood are associated with the progression from simple steatosis to NASH (50). Here, CD8A is linked to metabolic dysfunction-associated steatohepatitis.