In fact, it has been shown that the expression of adiponectin was reduced after at least 20 weeks of HFD (69); b) the diet composition in fatty acids elicited an interference (satured/monounsatured/polyunsatured) (70, 71); c) diet-induced overweight/metabolic syndrome is not always associated with decreased adiponectin levels in rats (72). This evidence concerns the gene ADIPOQ and metabolic syndrome.