PRL and pituitary apoplexy: In particular, at our center, pituitary surgery was proposed as first line treatment choice in cases with pituitary apoplexy, cystic PRL-secreting pituitary tumors, macro-PRL-oma in patients with a psychiatric condition for which dopamine agonists were contraindicated, or after a joint and multidisciplinary discussion between endocrinologists, neurosurgeons, and patients, concerning risks and benefits, with the final choice based upon the patient’s preference (11).