HPGDS and prion disease: The KEGG pathway enrichment analysis revealed a significant increase in proteins involved in the process of neurodegeneration, neuroinflammation, and oxidative stress (for example, prion disease pathway proteins—C1qs and Stip1; Chagas disease pathway proteins—serine/threonine-protein phosphatase 2A (PP2A) related proteins; glutathione pathway proteins such as glutathione S-transferase and peroxiredoxin-6) (Supplementary Table 4, Supplementary Figure 2).