Even though in vitro experiments demonstrated that macrophage conditioned medium attenuated cold-induced brown adipocyte activity (Kern et al., 2014) and that the activation of receptors that mediate LPS pathway (such as TLR4, TLR2, and NOD1) inhibited UCP1 and mitochondrial respiration in brown adipocytes (Bae et al., 2014), in the present study, no significant effects of CLP-induced sepsis in expression of thermogenic and mitochondrial activity-related genes were observed. Here, TLR4 is linked to Sepsis.