Similarly with the results acquired from the high fat diet and low dose STZ-induced diabetic rats, ob/ob mice, and db/db mice (Ye et al., 2017; Giuliani, 2019; Arow et al., 2020; Chen et al., 2020), the present study demonstrated that treatment with Dap for 8 weeks successfully improved cardiac dysfunction and reduced myocardial fibrosis and apoptosis in STZ-induced diabetic mice. This evidence concerns the gene DAP and Myocardial fibrosis.