Recent studies have suggested that biological therapies inhibition cytokines promote inflammation (e.g., anti–tumor necrosis factor TNF antibodies) or modulation of lymphocyte trafficking are effective in many IBD patients, implying that targeting dysregulated immune responses may be a potential therapeutic treatment in the future (Kaser et al., 2010; Kobayashi et al., 2020; Roda et al., 2020). Here, TNF is linked to inflammatory bowel disease.