The studies by Bauer et al. (Bauer et al., 2010; Bauer et al., 2012; Mak'Anyengo et al., 2018) showed that mice lacking NLRP3 exhibited attenuated colitis compared to control mice in both DSS- and TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced models. Here, NLRP3 is linked to colitis.