NLRP3 and inflammatory bowel disease: In addition, pharmacological inhibition of NLRP3 inflammasome activation ameliorates intestinal inflammation in animal models, suggesting that the NLRP3 inflammasome is a candidate target for treatment of IBD (Bauer et al., 2010; Du et al., 2017; Zhao Y. et al., 2019; Mei et al., 2019).