Importantly, Apt@GO@Au-His@a-ZnO@DOX NCs exhibited much higher targeting efficacy and tumor inhibition to EGFR-positive A549 cells than that of GO@Au-His@a-ZnO@DOX NCs according to the laser scanning confocal microscope (LSCM) images for cellular uptake and in vivo experiments (Figure 5B). This evidence concerns the gene EGFR and neoplasm.