circMYBL2 has been reported to regulate FMS-like tyrosine kinase-3 (FLT3) translation by recruiting polypyrimidine tract-binding protein 1 (PTBP1) to promote FLT3-internal tandem duplication in acute myeloid leukemia progression (Sun et al., 2019). The gene discussed is PTBP1; the disease is acute myeloid leukemia.