We also speculate that targeting NAV2 might not only affect inflammation in RA but also interfere with a major type of cell-cell interaction involved in the sensitization of joint-innervating neurons, which drive pain in arthritis.12 Therefore, NAV2 provides an attractive novel target for intervention in inflammatory diseases, especially RA, and we are quite eager to learn more. Here, NAV2 is linked to rheumatoid arthritis.