In addition, Western blot analysis of cell lysates from the xenografted tumor tissues showed that silencing kindlin-2 in mice inoculated with kindlin-2-knockdown tumor cells led to decreased phosphorylation levels of the JNK and p38 proteins, while kindlin-2 overexpression led to increased phosphorylation levels of the JNK and p38 proteins; however, this increase was inhibited by 1A-116 (Fig. S12). The gene discussed is MAPK8; the disease is neoplasm.