Kindlin-2 knockdown in MeWo dramatically suppressed the phosphorylation of the JNK, p38, and ERK proteins, but had nearly no effect on the levels of total JNK, p38, and ERK, while in WM35 melanoma cells (harbored the BRAF mutations) with kindlin-2 knockdown, the phosphorylation of the JNK and p38 proteins were decreased, but had nearly no effect on the levels of total JNK and p38. This evidence concerns the gene MAPK8 and melanoma.