In the present study, we aimed to elucidate the role of miR-210-3p in regulating autophagy and inflammatory activation in septic ALI and the intrinsic mechanism, and our results indicated that plasma EV-mediated delivery of miR-210-3p targets ATG7 to regulate autophagy and inflammatory activation in sepsis-induced ALI. The gene discussed is ATG7; the disease is Sepsis.