The precancerous lesions that have reached the limit of telomere shortening may be in crisis, which leads to immortalization by releasing the previously suppressed expression of TERT. Therefore, identification of a novel telomerase repressor gene(s) on the 3p21.3 chromosomal region may facilitate our understanding of the molecular mechanisms in the multistage carcinogenesis model for PC, especially in the late stages. The gene discussed is TERT; the disease is pachyonychia congenita.