ITGB1 and atherosclerosis: Further, detecting not only Itgb1 but also Sema7a as up-regulated is remarkable given that endothelial Semaphorin 7A is known to promote neutrophil migration during hypoxia44 and that vascular Semaphorin 7A up-regulation has been shown to promote atherosclerosis through endothelial β1 integrin45.