Among these genes, Mcam encodes a vascular wall component that plays a prominent role in cancer metastasis and developing tissues by, on the one hand, serving as a receptor for multiple pro-angiogenic factors (as Wnt5a, Netrin-1, FGF4, VEGF-C and Wnt1) and, on the other, allowing rapidly proliferating cells to migrate more effectively via cell–cell and cell-ECM interactions90. This evidence concerns the gene VEGFC and cancer.