Thus, this study was designed to investigate the function of exosomal miR-1260b by investigating how exosomal miR-1260b induced angiogenesis in endothelial cells and cellular mobility in NSCLC cells by targeting HIPK2 to determine whether exosomal miR-1260b could serve as a predictive indicator for metastasis in NSCLC. This evidence concerns the gene HIPK2 and non-small cell lung carcinoma.