Also, it has been suggested that dual blockade of programmed cell death protein 1 (PD1), lymphocyte activation gene 3 (LAG-3), or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) using genome editing technologies can sustain the improved T cell effector activities, facilitating an abrogation in tumor growth [8]. This evidence concerns the gene LAG3 and neoplasm.