INS and diabetes mellitus: This research showed micro RNA 29a was down regulated in participants with positive family history of diabetes which is in accordance with many studies; Lin et al. quantified miR-29a and was found down regulated in glomeruli of diabetic mice [15] while another study revealed MiR-29a knockout mice showed higher blood glucose levels when compared with wild type due defect in insulin secretion while insulin production was found to be normal [5].