KRAS and metastatic colorectal cancer: The additional two cases both achieved clinical response, and the patient with breast cancer who was treated with T cell therapy in combination with interleukin-2 and ICI showed complete durable regression for more than 22 months while the patient with metastatic colorectal cancer who only received infusion with KRAS-G12D targeted TILs progressed 9 months after therapy [55, 56].