What is more is that the related downstream pathways, such as AMP-activated protein kinase/Sirtuin1 (AMPK/SIRT1), phosphatidylinositol-3-kinases/protein kinase B (PI3K/AKT), and Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and the various therapies that target them for prevention IDD have become a hot research topic in recent times [6–9]. The gene discussed is STAT3; the disease is intervertebral disk degenerative disorder.