SNCA and Lewy body dementia: Examples of CNVs that have been proven to cause neurodegenerative diseases include duplications of APP leading to EOAD [3], multiplications of alpha-synuclein (SNCA) causing forms of Parkinson’s disease (PD) and DLB [4], as well as both deletions and duplications of PRKN that are known to cause forms of PD [5].