Interestingly, exogenously added α-syn fibrils induce lipid rafts-dependent endocytosis [25], with numerous PD-associated gene products, including parkin, DJ-1, and UCH-L1 also regulating lipid rafts-dependent endocytosis [22, 57, 58], indicating that the dysfunction of lipid rafts-dependent endocytosis may be associated with the pathogenesis of PD as a common pathological mechanism. This evidence concerns the gene PRKN and Parkinson disease.