HOOK3 and non-small cell lung carcinoma: Then, by performing the following gain-of-function experiments, we found that the rescuing effects of midazolam on cisplatin-sensitivity in CR-NSCLC cells were abolished by upregulating HOOK3, suggesting that midazolam downregulated HOOK3 to increase cisplatin-sensitivity in NSCLC, which indirectly reflected that HOOK3 participated in the regulation of drug resistance in NSCLC.