HOOK3 and non-small cell lung carcinoma: The MTT assay results showed that the inhibiting effects of midazolam plus cisplatin co-treatments on cell proliferation were abrogated by upregulating HOOK3 (Fig. 5A, B), which were supported by the following trypan blue staining assay results that HOOK3 overexpression rescued cell viability in the CR-NSCLC cells co-treated with midazolam and cisplatin (Fig. 5C, D).