FGF21 and prediabetes syndrome: FGF21/adiponectin ratio was a predictor of incident prediabetes (OR 1.185 [95% CI 1.026–1.369], p = 0.021) independent of traditional risk factors, whereas FGF21 and adiponectin alone did not significantly predict incident prediabetes (both p > 0.05) (Fig. 1).