Reasoning that associations of TRL and LDL particles characteristics with incident T2D could in part be dependent on cholesterol accumulation in pancreatic β-cells [45, 46], and that inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase could affect glucose tolerance and insulin secretion [55–57], secondary analyses were performed according to statin use. The gene discussed is HMGCR; the disease is type 2 diabetes mellitus.