CAT and intrahepatic cholangiocarcinoma: In order to validate proteomic data, we selected four among the up-regulated proteins found by previous analysis, all associated to overrepresented above mentioned processes; we evaluated CAT (n = 15), SODM, PRDX6 and DBI/ACBP (n = 11 for the last three proteins) protein expression by IHC in an independent case series of archival tissue samples derived from ICC Italian patients.