Thus, we aimed to explore the association of radiomics derived from 18F-fluorodeoxyglucose PET/CT imaging combined with COX-2 and TNC expressions with LVSI in early cervical cancer and to establish a machine learning model of the combination of PET/CT radiomics, COX-2, and TNC to predict LVSI in patients with early-stage cancer. This evidence concerns the gene TNC and cancer.