CPGs for the management of hypertension in Southeast Asia [30–35] were concordant with the recommendations in both the 2017 ACC/AHA guideline [26] and the 2018 ESC/ESH guideline [27] that ACE inhibitors, ARBs, and calcium channel blockers as the options for initial first-line therapy for patients with hypertension and no comorbidity. This evidence concerns the gene ACE and hypertensive disorder.