As for immune checkpoint molecules, the RRAGB mRNA expression was significantly associated with TNFSF4, TNFSF9, TNFSF18, TMIGD2, TNFRSF14, TNFRSF18 in COAD (all P < 0.05, Figure 8(a)). This evidence concerns the gene TNFSF18 and colon adenocarcinoma.