CD8A and infection: In addition, we also observed differences in T cell memory subset distribution (Fig. 4b and Extended Data Fig. 9a–c) of spike-specific early memory CD8+ T cells with higher fractions of more early differentiated subsets, for example, early differentiated (TED) and central memory (TCM) T cells for A*01/S865- and A*02/S269-specific CD8+ T cells and transitional memory cells for A*03/S378-specific CD8+ T cells after natural infection (80–120 dps).