CD274 and non-small cell lung carcinoma: The common standard of care in first-line therapy for NSCLC, without oncogenic drivers, involves use of platinum-based chemotherapy or immune checkpoint inhibitors (ICIs) either as single components or in combination, depending on the level of expression of programmed death-ligand 1 (PD-L1) or potential contraindications such as poor performance status, often found in patients of advanced age [8-12].